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Title：Biomimetic Heterogeneous Microcomponents on an Electro-Microfluidic Platform 

Time：10：00 AM,Jan 28th  

Place：F207, School of Mechanical Engineering

Speaker：Professor Shih-Kang Fan, Mechanical Engineering, National Taiwan University (NTU), Taiwan

Host：Pro ZHAO Changying

Abstract：

　　Synthesis and assembly of multi-functional, heterogeneous, and encoded microcomponents, or building blocks, are essential to engineering hierarchical, complex, and three-dimensional structures. The elaborately organized architectures devise metamaterials that hold new physical properties unusual in nature or artificial tissues that reappear physiological functions by imitating natural and biological arrangements. Here we demonstrate synthesis and assembly of microcomponents by electrowetting-on-dielectric (EWOD) and dielectrophoresis (DEP) on a robotic electro-microfluidic platform. The platform is capable of (1) driving different droplets of hydrogel prepolymers before cross-linking, (2) arranging particles or cells in the droplets, and (3) forming microcomponents by cross-linking droplets in different shapes. In the presentation, we will demonstrate the synthesis and assembly of different hydrogel microcomponents containing different dyes and particles. The heterogeneous structures with cell adhesive GelMA (gelatin methacrylate) and non-adhesive PEG-DA (Poly(ethylene glycol) diacrylate) surfaces are prepared for cell culture. The culture of fibroblasts NIH/3T3, neonatal mouse cardiomyocyte, and endothelia HUVEC on the engineered structures synthesized and assembled on the robotic electro-microfluidic platform will be reported.

Biography：

　　Professor Shih-Kang Fan is a world leading expert in Microlfuidics and Micro/Nano-Electro-Mechanical Systems. He received the B.S. degree from National Central University, Taiwan ROC, in 1996, the M.S. and Ph.D. degrees from University of California, Los Angeles (UCLA), USA, in 2001 and 2003, respectively. He joined the Institute of Nanotechnology at National Chiao Tung University as Assistant Professor in February 2004 and promoted to Associate Professor in August 2009. He moved to the Department of Mechanical Engineering, National Taiwan University in August 2012. His research interests are in the areas of microfluidics, nanomanipulations, and biochips.